Our team performs efficient screening assays covering the entire in vitro ADMET spectrum including solution properties, drug absorption and transport, metabolic stability and identification, drug-drug interactions and in vitro toxicity.
Solution Properties
Drug Metabolism and Pharmacokinetics (DMPK) is an integral part of drug discovery. Its central role is to contribute to the optimization of novel chemical entities in drug discovery by balancing the properties associated with drug gastrointestinal absorption (for orally delivered therapies), distribution, clearance, elimination and DDI potential as rapidly and cost-effectively as possible.
The DMPK department comprises in-vitro, in-vivo, metabolite ID and pre-formulation groups, managed by highly experienced and matured scientists. We guide discovery projects by troubleshooting scientific issues and offer changes on scaffolds to drive discovery projects in the right direction and de-risk failures in the later stage of development due to DMPK related issues.
